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The researchers survey at least a 50 % decrease in symptoms in two-thirds of patients with moderately serious depressive symptoms such as for example feeling hopeless, feeling poor about oneself or having trouble concentrating. They also discovered a 50 % decrease in stress symptoms in half of caregivers of individuals with dementia. Major depression and dementia, which typically impact other medical conditions, are difficult for primary care doctors to take care of during their limited period with patients, said Regenstrief Institute IU and investigator Center for Aging Research scientist Michael LaMantia, M.D., MPH, who led the scholarly research.