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A variety of statistical modeling, theoretical, and automated analytical approaches were used; some were conventional, their combined software to the study of introns was novel. The CARB study is unique in using an evolutionary model as the foundation for inferring the presence of ancestral introns. The extensive research was permitted partly by the increasing availability, over the past decade, of massive amounts of genetic sequence data. The business lead researcher is certainly Arlin B. Stoltzfus of NIST; collaborators consist of Wei-Gang Qiu, formerly of CARB and the University of Mayland and today at Hunter University in New York City, and Nick Schisler, at Furman University currently, Greenville, S.C.

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