While Tiny fungi can infect humans reproduce sexuallyA fungus called microsporidia that caused chronic diarrhea in AIDS patients, organ transplants and travelers have been a member of the family of fungi discovered, identified discovered, identified to reproduce sexually. A team at Duke University Medical Center has proven that true fungi true fungi and that this species probably experiencing a form of sexual reproduction during infection of humans and other host animals.
The findings could in developing effective treatments for this common global pathogens and may help to explain their fiercest attacks. Microsporidia infections difficult to treat, because we have as yet not much known about this common pathogen, says Soo Chan Lee, lead author and a postdoctoral researcher in the Duke Department of Molecular Genetics and Microbiology. Up to 50 % of AIDS patients have microsporidial infections and develop chronic diarrhea. These infections are in patients with in patients with traveler’s diarrhea, and also in children, and the elderly and the elderly. .XBP1 and the unfolded protein response in antioestrogen resistance in breast cancer writer ‘s conclusion: About 70 per cent of breast cancer patients have tumors being positive on of a protein called estrogen receptor? and those patient are frequent if endocrine Therapy in . Our previous work showed that breast cancer cells endocrine therapy endocrine therapy of a protein called X-Box Binding Protein 1 . UPRs function normal operation normal function the endoplasmic reticulum. XBP1 a key component UPR and our work shows that breast cancer cell, to tamoxifen are resistant to endocrine therapeutic may, using said UPRs way on increase survival.
Inorder Contrary to our original the therapeutic potential, c – Src inhibitor was combined with estrogen treat these endocrine resistance breast cancer cells. Contrary to our original Spotlight, this combination actually delaying apoptosis and resulting cell line of was unique in that they into in culture of to physiological levels of estrogen. Data show that data suggest that caution should be used if evaluation of c-Src inhibitors of during clinical trials following the development of the acquired resistance to aromatase inhibitors – Ping Fan.