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Advances in epilepsy treatment Epilepsy and seizures influence 2.5 million Americans, 181,000 new cases of epilepsy are diagnosed each year, and the disorder incurs around $12.5 billion in annual indirect and direct costs. About 450,000 children ages 15 and young develop epilepsy each complete year, and of these, 315,000 are school-aged children. Children and adolescents are more likely to have epilepsy of unidentified or genetic origin. The rate of new cases in children is definitely highest before age 2, declines until about age 10 gradually, and then stabilizes.