Raj R. Makkar, M.D., Gregory Fontana, M.D., Hasan Jilaihawi, M.D., Tarun Chakravarty, M.D., Klaus F. Kofoed, M.D., D.M.Sc., Ole de Backer, M.D., Ph.D., Federico M. Asch, M.D., Carlos E. Ruiz, M.D., Niels T. Olsen, M.D., Ph.D., Alfredo Trento, M.D., John Friedman, M.D., Daniel Berman, M.D., Wen Cheng, M.D., Mohammad Kashif, M.D., Vladimir Jelnin, M.D., Chad A. Kliger, M.D., Hongfei Guo, Ph.D., Augusto D. Pichard, M.D., Neil J. Weissman, M.D., Samir Kapadia, M.D., Eric Manasse, M.D., Deepak L. Bhatt, M.D., M.P.H., Martin B. Leon, M.D.D.: Feasible Subclinical Leaflet Thrombosis in Bioprosthetic Aortic Valves.A mutation was determined in the SEL1L gene, which has no previous link to inherited cerebellar ataxias. This gene find is the first in canine early-onset cerebellar degeneration, and has enabled the advancement of a genetic test to help eradicate the disease from the breed of dog. At the same time, SEL1L represents a novel candidate gene in human early-onset degenerative ataxias. The study was released in the scientific journal PLoS Genetics on June 14, 2012.
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