Explaining why current therapies sometimes fail perhaps.

Furthermore to looking for these antigens, Umetsu, Akbari and colleagues plan to look at milder asthma and lengthen their studies to kids to see if NKT cells play an identical role. They’ll also seek ways of switching off or counteracting NKT cells, which could be progressed into new drugs. Corticosteroids, which focus on Th2 cells and various other inflammatory cells, reduce irritation but may actually have little influence on NKT cells, Umetsu says. This probably explains why they don’t really always work in asthma. ‘If we can specifically get rid of NKT cells, we ought to be able to treat asthma a lot more effectively,’ Umetsu says..Minor reactions at the injection site had been frequent, especially induration, pain, and inflammation. There have been 114 adverse occasions in the fractional-dosage group, as compared with 11 in the full-dosage group. Among the 114 adverse events in the fractional-dosage group, 84 were redness at the injection site, 25 induration at the injection site, 3 a temperature of 38. All injection-site reactions but one involved an area smaller than 5 mm in diameter.