The ESCAPE Trial Group: Strict Blood-Pressure Control and Progression of Renal Failure in Children Among both adults and children, chronic kidney disease will progress to end-stage renal failure, that is a main clinical issue. Systemic hypertension and glomerular hyperfiltration result in progressive nephron damage.4-7 Children comprise significantly less than 1 percent of the total populace with chronic kidney disease and often have congenital kidney malformations, urinary tract disorders, or genetic disorders that affect nephron formation or function article .
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