Heather E. Hsu, M read article .P.H., Kathleen A. Shutt, M.S., Matthew R. Moore, M.D., M.P.H., Bernard W. Beall, Ph.D., Nancy M. Bennett, M.D., Allen S. Craig, M.D., Monica M. Farley, M.D., James H. Jorgensen, Ph.D., Catherine A. Lexau, Ph.D., M.P.H., Susan Petit, M.P.H., Arthur Reingold, M.D., William Schaffner, M.D., Ann Thomas, M.D., Cynthia G. Whitney, M.D., M.P.H., and Lee H. Harrison, M.D.: Effect of Pneumococcal Conjugate Vaccine on Pneumococcal Meningitis Streptococcus pneumoniae is the most common reason behind bacterial meningitis in the United States and many countries worldwide.1-4 Despite effective antimicrobial therapy, pneumococcal meningitis remains lethal and has significant long-term sequelae highly.4,5 The pediatric heptavalent pneumococcal conjugate vaccine has had a major effect on the incidence of pneumococcal disease in the usa.6 PCV7 not merely protects immunized children from pneumococcal disease7-11 but also provides security to nonimmunized children and adults through herd immunity, caused by reduced transmission of S.
The getting of a mutation that’s characteristic of adult-type GCTs in thecomas isn’t surprising because the distinction between thecomas and GCTs could be arbitrary and mixtures of the two types of tumor cells could be seen in specific tumors.21 The presence of the FOXL2 mutation in a subgroup of thecomas suggests a cut point upon this morphologic continuum between thecoma and GCT. Studies of additional patients with follow-up will be asked to determine whether thecomas with a FOXL2 mutation are biologically even more similar to GCTs than to mutation-negative thecomas. The three mutation-negative adult-type GCTs were challenging. Two of the tumors had immunohistochemical profiles which were unique from those of all GCTs, suggesting that these were not true GCTs but, rather, morphologic mimics.