‘We've shown abnormalities in brain framework connections may be enough to push you to definitely develop chronic pain after they have an injury.’ Based on MRI mind scans of individuals who had a new lower back injury, Northwestern researchers could predict with about 85 % accuracy which patients' pain would persist. The predictor was a specific irregularity or marker the researchers identified in the axons, pathways in the brain's white matter that connect mind cells so they can communicate with each other.Wiviott, M.D., Lei Shen, Ph.D., Richard D. Hockett, M.D., John T. Brandt, M.D., Joseph R. Walker, Pharm.D., Elliott M. Antman, M.D., William Macias, M.D., Ph.D., Eugene Braunwald, M.D., and Marc S. Sabatine, M.D., M.P.H.: Cytochrome P-450 Response and Polymorphisms to Clopidogrel Across the spectrum of acute coronary syndromes and in individuals undergoing percutaneous coronary interventions with stenting, dual antiplatelet therapy with clopidogrel and aspirin, a thienopyridine inhibitor of the platelet P2Y12 adenosine diphosphate receptor, is the standard of care.1-3 However, the pharmacodynamic response to clopidogrel has substantial interpatient variability,4-6 and patients with coronary disease with lesser examples of platelet inhibition in response to clopidogrel seem to be in increased risk for cardiovascular events.7-10 Clopidogrel is a prodrug that requires biotransformation to a dynamic metabolite by cytochrome P-450 enzymes .11,12 Moreover, esterases shunt nearly all clopidogrel to an inactive pathway, with the remaining prodrug requiring two individual CYP-dependent oxidative techniques.
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