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Study Design The study, that was conducted at 29 sites in the United Canada and States, was a randomized, double-blind, placebo-controlled, 12-week trial, which was accompanied by an open-label extension trial . Patients were enrolled from October 17, 2011, to June 22, 2012. Patients were randomly designated in a 1:1:1 ratio to receive brodalumab at dosages of 140 mg or 280 mg or placebo by subcutaneous injection on day time 1 and at weeks 1, 2, 4, 6, 8, and 10. Randomization was stratified regarding to prior biologic therapy . Randomization lists had been generated by Amgen representatives by using a permuted-block style within each stratum. At the full week 12 visit, patients who hadn’t discontinued their participation in the analysis were offered open-label brodalumab at a dosage of 280 mg once every 14 days for the remainder of the study.